Diagnosed with cadaan gene mutation disease

[Boomer]

I was just diagnosed with gene mutation related to iron problem or something. I carry a copy of a gene called h63d. I got the diagnosis after doctor ordered a genetic test after my blood results showed elevated iron and saturation. My doctor straight up said this aint African disease chief.
Make sense of this for me reer dna.

 

[Aurelian]

I was just diagnosed with gene mutation related to iron problem or something. I carry a copy of a gene called h63d. I got the diagnosis after doctor ordered a genetic test after my blood results showed elevated iron and saturation. My doctor straight up said this aint African disease chief.
Make sense of this for me reer dna.

Where from Somalia you are from ?

 

[Aurelian]

The gene is mostly in Europe, rare in Africa and East Asia, but it is prominent in South Asians as well

Europeans 17-27%
South Asians 7-17%

Asians and Africans 1-3%


So, in theory you could be one of the very unlucky Africans who got that disease, or you could have some South Asians in you.

 

[The truth seeker]

May Allah cure you sxb

 

[The alchemist]

The average Somali HLA profile can look different from what doctors class as typical "African," usually coded along West African-related ancestry (WA + Bantu). The dearth of research undertaken makes it hard to estimate the frequency among Somalis. It's not unrealistic to assume cases a bit higher than South African Bantus that were studied, narrowly ranging between the tail beginning of nill-to-rare cases.

It seems you have a heterozygous allele (one gene and one copy); am I right to speculate it is a mild condition?

May you get better, inshallah. I read that one can keep age-dependent accumulated disease problems at bay during the pre-clinical period via venesection through blood extraction until one sees normal iron levels affording a normal life span. Is that what your doctor is looking for if you have hemochromatosis?

 

[Boomer]

Where from Somalia you are from ?

I am Ogaden. Mom is from Gedo(her parents from Galbeed) while my dad is from Galbeed.

 

[Boomer]

May Allah cure you sxb

Thank you wll!

 

[Boomer]

The gene is mostly in Europe, rare in Africa and East Asia, but it is prominent in South Asians as well

Europeans 17-27%
South Asians 7-17%

Asians and Africans 1-3%


So, in theory you could be one of the very unlucky Africans who got that disease, or you could have some South Asians in you.

My brother did his dna a while back and it came back like 97.5 % somali with the rest being Ethiopian and Eritrean so i am sure there’s no Asian in us.

 

[Boomer]

The average Somali HLA profile can look different from what doctors class as typical "African," usually coded along West African-related ancestry (WA + Bantu). The dearth of research undertaken makes it hard to estimate the frequency among Somalis. It's not unrealistic to assume cases a bit higher than South African Bantus that were studied, narrowly ranging between the tail beginning of nill-to-rare cases.

It seems you have a heterozygous allele (one gene and one copy); am I right to speculate it is a mild condition?

May you get better, inshallah. I read that one can keep age-dependent accumulated disease problems at bay during the pre-clinical period via venesection through blood extraction until one sees normal iron levels affording a normal life span. Is that what your doctor is looking for if you have hemochromatosis?

Yes it’s just one copy but man my symptoms were pretty devastating. From severe brain fog to 24 hour liver pain. My liver function also showed elevated numbers and I have never had a drink in my life. Doctors were surprised to see such severe symptoms with only one copy. I have been put on regular blood removal schedule and it’s helping alhamdulilah.
they think this mutation developed in the celtic lande, but as usual cadaans don’t invest in medical research elsewhere.

 

[The alchemist]

Yes it’s just one copy but man my symptoms were pretty devastating. From severe brain fog to 24 hour liver pain. My liver function also showed elevated numbers and I have never had a drink in my life. Doctors were surprised to see such severe symptoms with only one copy. I have been put on regular blood removal schedule and it’s helping alhamdulilah.
they think this mutation developed in the celtic lande, but as usual cadaans don’t invest in medical research elsewhere.

Inshalla, bro. Things will get better for you. Pray to Allah for help, the treatments will alleviate the pains and problems.

The disease is more prevalent in places like Norway. The version that you have is carried by people between 12-15%.

I found one study that represented Oromo and Amhara samples classified as Central Ethiopians, and for a separate mutation in the HFE gene that causes hemochromatosis named Cys282Tyr, they got zero frequency:

While the one you carry was different in that they had elevated values (Oromos and Amharas, that is):

This mutation called His63Asp is essentially the same as the one you called H63D. That mutation, as you will notice, has 9.4% frequencies among Oromo and Amharas. Basically in heterozygous conditions, similar to you. It has a 1.1% homozygous condition which usually leads to more potential for increased cases of iron build-up. The value appears higher than Mozabites who are Berber (though they had no homozygous conditions, which could be because they had half the sample size compared to the Ethiopians. Or maybe not).

It seems like Cys282Tyr (C282Y) is strongly tied to the Celtic and Viking disease, while H63D is much older and is less associated, but is in a weaker sense, associated with iron buildup without necessarily a full-blown clinical hemochromatosis. However, it can cause the symptoms you mentioned, with other health issues.

Did your doctor say you had hemochromatosis or just iron buildup and liver problems?

We see 8.3% of Oromo and Amhara got one copy of H63D while 1.1% had both alleles as GG which means those people could be more susceptible to having stronger symptoms, despite it having nothing to do with Celts, at least, directly.

In another study, it shows that H63D is ~15.17% in Tunisia with ~0.09% for C282Y. In Egypt, you had ~20% for H63D, with no cases for C282Y. For Moroccans, this went up to 27% and 0.9% heterozygotes and homozygotes of H63D, respectively.

H63D is not as uncommon as one had assumed outside Europe. Rationally speaking, the way it does not appear among Senegalese, I would think this was introduced through the Eurasian side. Yet, we see no cases of C282Y among the Ethiopians, pointing out that this one is more European-related. Tunisians and Moroccans who barely had any, received European gene flow from Iberia, during pre-history, down to well within the Common Era period through diversified and lesser frequency via the Mediterranean.

 

[Boomer]

Inshalla, bro. Things will get better for you. Pray to Allah for help, the treatments will alleviate the pains and problems.

The disease is more prevalent in places like Norway. The version that you have is carried by people between 12-15%.

I found one study that represented Oromo and Amhara samples classified as Central Ethiopians, and for a separate mutation in the HFE gene that causes hemochromatosis named Cys282Tyr, they got zero frequency:
View attachment 350202

While the one you carry was different in that they had elevated values (Oromos and Amharas, that is):
View attachment 350203

This mutation called His63Asp is essentially the same as the one you called H63D. That mutation, as you will notice, has 9.4% frequencies among Oromo and Amharas. Basically in heterozygous conditions, similar to you. It has a 1.1% homozygous condition which usually leads to more potential for increased cases of iron build-up. The value appears higher than Mozabites who are Berber (though they had no homozygous conditions, which could be because they had half the sample size compared to the Ethiopians. Or maybe not).

It seems like Cys282Tyr (C282Y) is strongly tied to the Celtic and Viking disease, while H63D is much older and is less associated, but is in a weaker sense, associated with iron buildup without necessarily a full-blown clinical hemochromatosis. However, it can cause the symptoms you mentioned, with other health issues.

Did your doctor say you had hemochromatosis or just iron buildup and liver problems?

We see 8.3% of Oromo and Amhara got one copy of H63D while 1.1% had both alleles as GG which means those people could be more susceptible to having stronger symptoms, despite it having nothing to do with Celts, at least, directly.

In another study, it shows that H63D is ~15.17% in Tunisia with ~0.09% for C282Y. In Egypt, you had ~20% for H63D, with no cases for C282Y. For Moroccans, this went up to 27% and 0.9% heterozygotes and homozygotes of H63D, respectively.

H63D is not as uncommon as one had assumed outside Europe. Rationally speaking, the way it does not appear among Senegalese, I would think this was introduced through the Eurasian side. Yet, we see no cases of C282Y among the Ethiopians, pointing out that this one is more European-related. Tunisians and Moroccans who barely had any, received European gene flow from Iberia, during pre-history, down to well within the Common Era period through diversified and lesser frequency via the Mediterranean.

Very interesting read, thanks for taking the time. They did a full mri scan on my organs and found no deposition of iron, although my liver function test were off the charts like I was a chronic alcoholic lol. My iron was also high not crazy levels, but what stood out was the saturation. It was like 91% and apparently above 45% is a cause for concern. The doctor eventually told me to do the genetic test and yes he diagnosed me with hemochromatosis. I am also on less red meat diet which I am not happy about. Doctor said even though i am not loading iron, i have too much free iron roaming around the body and that itself can cause damage to organs and this damage isn’t seen on scans. Anyways, interesting to know that there’s one specific to cadaans and one common outside of Europe.

thanks for the well wishes young brother:

 

[NidarNidar]

Inshalla, bro. Things will get better for you. Pray to Allah for help, the treatments will alleviate the pains and problems.

The disease is more prevalent in places like Norway. The version that you have is carried by people between 12-15%.

I found one study that represented Oromo and Amhara samples classified as Central Ethiopians, and for a separate mutation in the HFE gene that causes hemochromatosis named Cys282Tyr, they got zero frequency:
View attachment 350202

While the one you carry was different in that they had elevated values (Oromos and Amharas, that is):
View attachment 350203

This mutation called His63Asp is essentially the same as the one you called H63D. That mutation, as you will notice, has 9.4% frequencies among Oromo and Amharas. Basically in heterozygous conditions, similar to you. It has a 1.1% homozygous condition which usually leads to more potential for increased cases of iron build-up. The value appears higher than Mozabites who are Berber (though they had no homozygous conditions, which could be because they had half the sample size compared to the Ethiopians. Or maybe not).

It seems like Cys282Tyr (C282Y) is strongly tied to the Celtic and Viking disease, while H63D is much older and is less associated, but is in a weaker sense, associated with iron buildup without necessarily a full-blown clinical hemochromatosis. However, it can cause the symptoms you mentioned, with other health issues.

Did your doctor say you had hemochromatosis or just iron buildup and liver problems?

We see 8.3% of Oromo and Amhara got one copy of H63D while 1.1% had both alleles as GG which means those people could be more susceptible to having stronger symptoms, despite it having nothing to do with Celts, at least, directly.

In another study, it shows that H63D is ~15.17% in Tunisia with ~0.09% for C282Y. In Egypt, you had ~20% for H63D, with no cases for C282Y. For Moroccans, this went up to 27% and 0.9% heterozygotes and homozygotes of H63D, respectively.

H63D is not as uncommon as one had assumed outside Europe. Rationally speaking, the way it does not appear among Senegalese, I would think this was introduced through the Eurasian side. Yet, we see no cases of C282Y among the Ethiopians, pointing out that this one is more European-related. Tunisians and Moroccans who barely had any, received European gene flow from Iberia, during pre-history, down to well within the Common Era period through diversified and lesser frequency via the Mediterranean.

that's mad, for those of us who took 23andme and downloaded our raws, the snp for it rs1800562.

rs1800562 - SNPedia

www.snpedia.com

Very interesting read, thanks for taking the time. They did a full mri scan on my organs and found no deposition of iron, although my liver function test were off the charts like I was a chronic alcoholic lol. My iron was also high not crazy levels, but what stood out was the saturation. It was like 91% and apparently above 45% is a cause for concern. The doctor eventually told me to do the genetic test and yes he diagnosed me with hemochromatosis. I am also on less red meat diet which I am not happy about. Doctor said even though i am not loading iron, i have too much free iron roaming around the body and that itself can cause damage to organs and this damage isn’t seen on scans. Anyways, interesting to know that there’s one specific to cadaans and one common outside of Europe.

thanks for the well wishes young brother:

You got unlucky brother, I just checked and my granny is a carrier for H63D but not C282Y, while I don't carry it.

One copy of C282Y, carrier of hemochromatosis, likely unaffected unless also H63D carrier.

 

[The alchemist]

that's mad, for those of us who took 23andme and downloaded our raws, the snp for it rs1800562.

I have G/G. No mutation.

 

[Boomer]

that's mad, for those of us who took 23andme and downloaded our raws, the snp for it rs1800562.

rs1800562 - SNPedia

www.snpedia.com

You got unlucky brother, I just checked and my granny is a carrier for H63D but not C282Y, while I don't carry it.

One copy of C282Y, carrier of hemochromatosis, likely unaffected unless also H63D carrier.

Which one is worse? It seems both genes going rogue and mutating is bad but at least the cy281 is clear in what it messes up. The one I have is sneaky little . I am glad i know though alhamdulilah.

 

[TheManWhoIsAlive]

I was just diagnosed with gene mutation related to iron problem or something. I carry a copy of a gene called h63d. I got the diagnosis after doctor ordered a genetic test after my blood results showed elevated iron and saturation. My doctor straight up said this aint African disease chief.
Make sense of this for me reer dna.

I had a similar thing happen to me when I did a blood test. I never did a DNA test, but the test stated that I had high iron absorption. I think the condition is called hemochromatosis. It's apparently more common among Irish people and stuff. Dunno what the hell to make of it. Probably something in the water

 

[NidarNidar]

Which one is worse? It seems both genes going rogue and mutating is bad but at least the cy281 is clear in what it messes up. The one I have is sneaky little . I am glad i know though alhamdulilah.

If you carry C282Y and cy281 you'll have issues but if you're carrier of one, the symptoms won't appear.