Espaa_
Ku sali nabiga {scw}
I was reading into this as one of my uncle recently died this year due to a stroke (AUN). One drug he was given was a short term clot buster called tpa and a long term clot buster called warfarin. These drugs seem to not work in us but in other populations. I have searched if anyone else talked about this and came across this post by this user:
One very important thing that I have learnt and researched from this persons post is the gene VKORC1. This gene was discovered only recently in 2003 and has a couple of its own alleles. These are: VKORC1*1, VKORC1*2, VKORC1*3 and VKORC1*4. These are haplotypes with its own set of Alleles.
In Somalis, we have each allele at a frequency of:
VKORC1*2 (43%)
VKORC1*3 (32%)
VKORC1*4 (14%)
VKORC1*1 (wild type) (11%)
Somalis display a 60/40 Nilotic Natufian admixture but these results are bizzare because its extremely close to west eurasian population figures. Wild type just means the original unmutated human allele
SUB SAHARAN FREQUENCIES:
VKORC1*1 (wild type) 95%
VKORC1*2 <5%
VKORC1*3 <2%
VKORC1*4 <2%
within VKORC1*2 haplotype, it has 3 alleles which are rs2359612, rs8050894 and rs9934438. These are linked to lower warfarin resistance in Europeans and Asians. In somali populations, it is in linkage disequilibrium meaning its inherited more often than by chance.
There is another mutation called the Asp36Tyr that is completely separate factor to the haplotype system and influences warfarin resistance. In Somali populations, in a study of 95 people, 16 people carry this allele. That makes it approximately ≈17% of us which carry this separate allele meaning it is extremely hard for those people to be administered any warfarin and subsequently tpa for a stroke as they may not respond as efficiently.
Theres so much to write about including own reports for tPa itself as it has its own genes influencing it but the post would be too long. But all the genetic experts pls come on in.
took all your usernames from the fkdspot and thought you guys might want to check it out @giire12 @Garaad Awal @Fez @Juke @Step a side @Pastoralist @NidarNidar @TheLand you guys seem knowledgeable about genetics and somehow admixture plays a MASSIVE role in this. Researching this could save countless Somali lives as there are not many studies are on the effects of this gene on our ethnicity
ALL SOURCES: https://www.nature.com/articles/s41598-020-62645-0
everyone pls feel free to drop any opinions or anything about this in general.
Somalis and blood thinners do not mix.
Hello my fellow people. We as an ethnic group should be cautious when taking blood thinners like warfarin, especially if any of our family members have suffered a stroke or are at risk for blood clots. Genetic factors common in some of us may affect how our bodies respond to these medications...
www.somalispot.com
One very important thing that I have learnt and researched from this persons post is the gene VKORC1. This gene was discovered only recently in 2003 and has a couple of its own alleles. These are: VKORC1*1, VKORC1*2, VKORC1*3 and VKORC1*4. These are haplotypes with its own set of Alleles.
In Somalis, we have each allele at a frequency of:
VKORC1*2 (43%)
VKORC1*3 (32%)
VKORC1*4 (14%)
VKORC1*1 (wild type) (11%)
Somalis display a 60/40 Nilotic Natufian admixture but these results are bizzare because its extremely close to west eurasian population figures. Wild type just means the original unmutated human allele
SUB SAHARAN FREQUENCIES:
VKORC1*1 (wild type) 95%
VKORC1*2 <5%
VKORC1*3 <2%
VKORC1*4 <2%
within VKORC1*2 haplotype, it has 3 alleles which are rs2359612, rs8050894 and rs9934438. These are linked to lower warfarin resistance in Europeans and Asians. In somali populations, it is in linkage disequilibrium meaning its inherited more often than by chance.
There is another mutation called the Asp36Tyr that is completely separate factor to the haplotype system and influences warfarin resistance. In Somali populations, in a study of 95 people, 16 people carry this allele. That makes it approximately ≈17% of us which carry this separate allele meaning it is extremely hard for those people to be administered any warfarin and subsequently tpa for a stroke as they may not respond as efficiently.
Theres so much to write about including own reports for tPa itself as it has its own genes influencing it but the post would be too long. But all the genetic experts pls come on in.
took all your usernames from the fkdspot and thought you guys might want to check it out @giire12 @Garaad Awal @Fez @Juke @Step a side @Pastoralist @NidarNidar @TheLand you guys seem knowledgeable about genetics and somehow admixture plays a MASSIVE role in this. Researching this could save countless Somali lives as there are not many studies are on the effects of this gene on our ethnicity
ALL SOURCES: https://www.nature.com/articles/s41598-020-62645-0
everyone pls feel free to drop any opinions or anything about this in general.
Last edited:
. Thank you for letting me know.
